SON regulates GATA-2 via microRNA
نویسندگان
چکیده
Moores UCSD Cancer Center, University of California San Diego, La Jolla, CA 92093, USA Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA Department of Pathology and Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA Current address: Department of Cellular Pharmacology, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan Current address: Boston University School of Medicine, Center for Advanced Biomedical Research, Boston, MA 02118, USA
منابع مشابه
Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region.
Cis elements that mediate transcription factor binding are abundant within genomes, but the rules governing occupancy of such motifs in chromatin are not understood. The transcription factor GATA-1 that regulates red blood cell development binds with high affinity to GATA motifs, and initial studies suggest that these motifs are often unavailable for occupancy in chromatin. Whereas GATA-2 regul...
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Transcriptional networks orchestrate complex developmental processes, and such networks are commonly instigated by master regulators for development. By now, considerable progress has been made in elucidating GATA factor-dependent genetic networks that control red blood cell development. Here we reported that GATA-1 and GATA-2 co-regulated the expression of two microRNA genes, microRNA-27a and ...
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UNLABELLED The TOR (target of rapamycin [sirolimus]) is a universally conserved kinase that couples nutrient availability to cell growth. TOR complex 1 (TORC1) in Schizosaccharomyces pombe positively regulates growth in response to nitrogen availability while suppressing cellular responses to nitrogen stress. Here we report the identification of the GATA transcription factor Gaf1 as a positive ...
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Interplay among GATA transcription factors is an important determinant of cell fate during hematopoiesis. Although GATA-2 regulates hematopoietic stem cell function, mechanisms controlling GATA-2 expression are undefined. Of particular interest is the repression of GATA-2, because sustained GATA-2 expression in hematopoietic stem and progenitor cells alters hematopoiesis. GATA-2 transcription i...
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The zinc finger transcription factor GATA-2 has been implicated in the regulation of hematopoietic stem cells. Herein, we explored the role of GATA-2 as a candidate regulator of the hematopoietic progenitor cell compartment. We showed that bone marrow from GATA-2 heterozygote (GATA-2 / ) mice displayed attenuated granulocyte-macrophage progenitor function in colony-forming cell (CFC) and serial...
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